Aminobenzoic acids and derivatives
AdipoGen Butyryloxy-pyren-trisulfonic
Chemical. CAS 115787-82-1. Formula C20H13Na3O11S3. MW 594.48. Synthetic. Highly water soluble enzyme substrate for the fluorimetric assay of esterases at longwave excitation and emission wavelengths.
AdipoGen Pseudoanguillosporin A
Chemical. CAS 1159392-22-9. Formula C17H26O3. MW 278.4. Isolated from Strobilurus sp. Antifungal. Respiration inhibitor. Inhibits mitochondrial respiration in fungi. Binds at the Q0-centre on cytochrome b and blocks the electron transfer between cytochrome b and cytochrome c1.
AdipoGen Ansatrienin A
Chemical. CAS 82189-03-5. Formula C36H48N2O8. MW 636.8. Isolated from Streptomyces collinus. Antibiotic. Antitumor compound. Antifungal. Inhibits osteoclastic bone resorption.
AdipoGen -Brefeldin A
Chemical. CAS 20350-15-6. Formula C16H24O4. MW 280.4. Isolated from Eupenicillium brefeldianum. Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor Arf inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor Reviews.
AdipoGen Chaetoglobosin F
Chemical. CAS 55945-75-0. Formula C32H38N2O5. MW 530.7. Isolated from Chaetomium sp. Cytochalasan mycotoxin, derivative of chaetoglobosin A Prod. No. BVT-0092 http//www.adipogen.com/bvt-0092/chaetoglobosin-a.html . Phytotoxic. Cytotoxic against HCT116 human colon cancer cells. Antibacterial Ps. aeruginosa. Anti-inflammatory and immunomodulatory compound.
AdipoGen Cochliodone A
Chemical. CAS 1072931-48-6. Formula C34H38O12. MW 638.7. Isolated from Chaetomium sp. Dimeric spiro-azaphilone. Mycotoxin.
AdipoGen Eremofortin A
Chemical. CAS 62445-06-1. Formula C17H22O5. MW 306.4. Isolated from Penicillium roqueforti. Eremophilane sesquiterpene. Nontoxic secondary metabolite from Penicillium roqueforti.
AdipoGen Chaetoviridin A
Chemical. CAS 128252-98-2. Formula C23H25ClO6. MW 432.9. Isolated from Chaetomium sp. Azaphilone antibiotic. Antifungal compound phytopathogenic fungi. Cholesteryl ester transfer protein CETP inhibitor. Improves blood lipid levels. Monoamine oxidase inhibitor.
AdipoGen Pseudoanguillosporin A
Chemical. CAS 1159392-22-9. Formula C17H26O3. MW 278.4. Isolated from Strobilurus sp. Antifungal. Respiration inhibitor. Inhibits mitochondrial respiration in fungi. Binds at the Q0-centre on cytochrome b and blocks the electron transfer between cytochrome b and cytochrome c1.
AdipoGen Aurantimycin A
Chemical. CAS 162478-50-4. Formula C38H64N8O14. MW 857. Isolated from Streptomyces aurantiacus JA 4570. Depsipeptide antibiotic. Active against Gram-positive bacteria. Cytotoxic agent. Nematocide activity. Antiulcer agent. Anti-inflammatory drug C5a antagonist.
AdipoGen Papyracillic acid A
Chemical. CAS 960148-59-8. Formula C11H14O5. MW 226.2. Isolated from Lachnum papyraceum and a Microsphaeropsis sp. Antibiotic. Exists in an equilibrium of diastereomers.
AdipoGen Thaxtomin A
Chemical. CAS 122380-18-1. Formula C22H22N4O6. MW 438.4. Isolated from Streptomyces bottropensis Gö-Dra 17. Diketopiperazine antibiotic. Phytotoxin. Herbicide. Natural cellulose synthesis inhibitor. Plant cell necrosis inducer. Induces common scab disease of potato.
AdipoGen Isatropolone A
Chemical. Formula C24H24O9. MW 456.5. Isolated from Streptomyces rubiginosohelvolus Gö66. Cytostatic. Cytotoxic 3-10 µM.
AdipoGen Globosuxanthone A
Chemical. CAS 917091-74-8. Formula C15H12O7. MW 304.3. Isolated from fungus species unknown. Potent anticancer agent. Inhibits cell growth, proliferation and survival of human tumor cells lines in vivo and in vitro. Exhibits strong cytotoxicity against a panel of human solid tumor cell lines, disrupting the cell cycle leading to the accumulation of cells in either G2/M or S phase and inducing classic signs of apoptosis. Antifungal agent against Candida albicans.
AdipoGen Cyclosporin A
Chemical. CAS 59865-13-3. Formula C62H111N11O12. MW 1202.6. Isolated from Tolypocladium inflatum. Potent immunosuppressant same as FK-506 Prod. No. AG-CN2-0047 and rapamycin Prod. No. AG-CN2-0025. Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin. Prevents the dephosphorylation of nuclear factor of activated T cells NFAT transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor.